Bryskier A, Elbaz P, Fourtillan J B, Ortonne J P
Pathol Biol (Paris). 1984 Jun;32(5 Pt 2):506-8.
Extravascular diffusion of cefotiam was studied by a suction blister technique. Maximal cefotiam concentration in blister fluid (18.4 +/- 6.4 micrograms X ml-1) was found one hour after intravenous injection of a 1 g bolus. The area under the curve (AUC) of blister fluid concentrations was 35.4 micrograms X ml-1. Apparent elimination half-life from blister fluid was 0.72 hour. The AUC plasma/AUC blister fluid ratio approximated 1.
采用吸疱技术研究了头孢替安的血管外扩散。静脉注射1g大剂量药物1小时后，疱液中头孢替安的最大浓度为（18.4±6.4）μg/ml。疱液浓度曲线下面积（AUC）为35.4μg/ml。疱液中的表观消除半衰期为0.72小时。血浆AUC与疱液AUC之比约为1。
