Bruinink A, Lichtensteiger W
J Neurochem. 1984 Aug;43(2):578-81. doi: 10.1111/j.1471-4159.1984.tb00937.x.
The ontogeny of beta-adrenergic binding sites was studied in forebrain homogenates from male and female rats. Specific [3H]dihydroalprenolol binding was defined by the difference between binding in the presence and in the absence of 330 nM (+)oxprenolol. Significant binding was detected at prenatal stages. The dissociation constants (KD) of [3H]dihydroalprenolol binding were similar at gestational day (GD) 19 3/4 and postnatal day (PN) 31. Binding was first detected in forebrain at GD 15 3/4. The amount of binding sites increased until PN 31, when adult values were reached. No sex differences could be detected at any of the stages tested (GD 19 3/4-PN 31).
在雄性和雌性大鼠前脑匀浆中研究了β-肾上腺素能结合位点的个体发生。特异性[3H]二氢阿普洛尔结合通过在存在和不存在330 nM（+）氧烯洛尔时结合的差异来定义。在产前阶段检测到显著结合。[3H]二氢阿普洛尔结合的解离常数（KD）在妊娠第19 3/4天和出生后第31天相似。在妊娠第15 3/4天首次在前脑中检测到结合。结合位点的数量一直增加到出生后第31天达到成年值。在测试的任何阶段（妊娠第19 3/4天至出生后第31天）均未检测到性别差异。
