Murtazina A R, Bondarenko N S, Pronina T S, Chandran K I, Bogdanov V V, Dilmukhametova L K, Ugrumov M V
Institute of Developmental Biology RAS, Moscow, 119334 Russia.
Acta Naturae. 2021 Oct-Dec;13(4):89-97. doi: 10.32607/actanaturae.11516.
According to the literature, the cerebrospinal fluid (CSF) in the cerebral ventricles contains numerous neuron-derived physiologically active substances that can function as neurohormones and contribute to volume neurotransmission in the periventricular region of the brain. This study was aimed at carrying out a comparative analysis of CSF and the blood levels of monoamines in rats during ontogenesis as an indicator of age-related characteristics of monoamine transport to body fluids and their function as neurohormones in volume neurotransmission in the periventricular region of the brain. We have shown that CSF in the perinatal period and adulthood contains the most functionally significant monoamines: dopamine, noradrenaline, and serotonin. A comparison of the monoamine levels in the CSF and blood of animals of different age groups revealed that CSF contains monoamines of predominantly neuronal (cerebral) origin and almost no monoamines derived from the general circulation. We also established that monoamines are found in the CSF at physiologically active levels that allow them to act as neurohormones in both reversible volume neurotransmission in the adult brain and irreversible regulation of brain development in the perinatal period.
根据文献记载，脑室中的脑脊液（CSF）含有众多源自神经元的生理活性物质，这些物质可作为神经激素发挥作用，并有助于在脑室内周区域进行容积性神经传递。本研究旨在对大鼠个体发育过程中脑脊液和血液中的单胺水平进行比较分析，以此作为单胺向体液转运的年龄相关特征及其在脑室内周区域容积性神经传递中作为神经激素功能的指标。我们已经表明，围产期和成年期的脑脊液中含有功能上最重要的单胺：多巴胺、去甲肾上腺素和血清素。对不同年龄组动物脑脊液和血液中单胺水平的比较显示，脑脊液中的单胺主要源自神经元（脑），几乎不含来自体循环的单胺。我们还确定，脑脊液中的单胺处于生理活性水平，这使它们能够在成人大脑的可逆容积性神经传递以及围产期大脑发育的不可逆调节中充当神经激素。
