抗真菌唑类药物。7. 一系列新型三唑-3-酮的合成及抗真菌特性
Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones.
作者信息
Heeres J, Backx L J, Van Cutsem J
出版信息
J Med Chem. 1984 Jul;27(7):894-900. doi: 10.1021/jm00373a015.
PMID:6330360
Abstract
A series of novel triazol-3-ones have been synthesized, and their in vitro and in vivo antifungal properties are reported. Compound 68 (itraconazole), which displays a pronounced oral activity against vaginal candidosis in rats and against microsporosis in guinea pigs, has been selected for clinical evaluation.
摘要
已合成了一系列新型三唑-3-酮，并报道了它们的体外和体内抗真菌特性。化合物68（伊曲康唑）对大鼠阴道念珠菌病和豚鼠微孢子虫病显示出显著的口服活性，已被选作临床评估。
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