Monzul' G D, Kondrat'eva A P, Ratner T G, Lisovets S P
Med Radiol (Mosk). 1984 Jun;29(6):17-20.
A proton beam with the energy of 100-130 Mev, the range up to 40-100 mm and diameter up to 6 cm was used for radiation therapy of breast cancer metastases to the bones adjoining the vital organs or normal tissues with low tolerance (the skull, sternum, ribs, jaw, etc.). Medium fractionation regimens were used for the single doses of 4-10 Gy. The number of fractions was from 1 to 7, the summary dose 17-28 Gy that corresponded to 35-46 Gy of classic fractionation designed by the TDF factor. The first experience of the irradiation of bone metastases has shown that general and local reactions to proton irradiation correspond to a dose delivered and irradiation regimen and do not differ from those in conventional radiation. A marked therapeutic effect was obtained in all the patients. The formation of bigger diameter proton beams and of a deeper range is required for the irradiation of large zones of bone metastases.
能量为100 - 130兆电子伏特、射程达40 - 100毫米且直径达6厘米的质子束被用于对转移至毗邻重要器官或耐受性低的正常组织（颅骨、胸骨、肋骨、颌骨等）的乳腺癌骨转移灶进行放射治疗。单次剂量4 - 10戈瑞采用中等分割方案。分割次数为1至7次，总剂量为17 - 28戈瑞，这相当于由TDF因子设计的经典分割的35 - 46戈瑞。骨转移灶照射的首次经验表明，质子照射的全身和局部反应与所给予的剂量及照射方案相符，且与传统放疗的反应并无差异。所有患者均获得了显著的治疗效果。对于大面积骨转移灶的照射，需要形成更大直径和更深射程的质子束。
