人B淋巴细胞系中温度升高诱导γ-干扰素活性
Induction of gamma-interferon activity by elevated temperatures in human B-lymphoblastoid cell lines.
作者信息
Taylor M W, Long T, Martinez-Valdez H, Downing J, Zeige G
出版信息
Proc Natl Acad Sci U S A. 1984 Jul;81(13):4033-6. doi: 10.1073/pnas.81.13.4033.
Abstract
When the human B-lymphoblastoid cell lines GM3299 and GM4408 were heat shocked, elevated levels of antiviral activity were detected. This antiviral activity has been characterized as the result of de novo synthesis of interferon (IFN) gamma. Levels of antiviral activity as high as 20,000 units/ml per 10(6) cells were found after heat treatment. By using anti-IFN-alpha and anti-IFN-gamma sera, it was shown that the high antiviral activity in GM3299 after heat shock is due to a synergistic effect of constitutively produced IFN-alpha and induced IFN-gamma.
摘要
当人类B淋巴细胞系GM3299和GM4408受到热休克处理时，检测到抗病毒活性水平升高。这种抗病毒活性已被鉴定为干扰素（IFN）γ从头合成的结果。热处理后，每10⁶个细胞的抗病毒活性水平高达20,000单位/毫升。通过使用抗IFN-α和抗IFN-γ血清，结果表明热休克后GM3299中的高抗病毒活性是由组成性产生的IFN-α和诱导产生的IFN-γ的协同作用所致。
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