[环核苷酸在辐射过程中实现铜蓝蛋白作用的参与情况]
[Participation of cyclic nucleotides in realizing the effect of ceruloplasmin during irradiation].
作者信息
Antonenko S G, Berdinskikh N K, Chebotarev E E
出版信息
Radiobiologiia. 1984 May-Jun;24(3):334-6.
PMID:6330788
Abstract
It was shown that a single intraperitoneal administration of human ceruloplasmin 60 min before irradiation (4.22, 5.28 and 7.20 Gy) increases the content of cyclic AMP and cyclic GMP in the thymus and spleen of rats 3 and 6 h following X-irradiation. Ceruloplasmin increases the cyclic AMP/cyclic GMP ratio in the above-mentioned rat organs in normal conditions and on radiation pathology.
摘要
结果表明，在照射（4.22、5.28和7.20戈瑞）前60分钟单次腹腔注射人铜蓝蛋白，可使大鼠在X线照射后3小时和6小时时胸腺和脾脏中环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的含量增加。在正常条件下以及辐射病理状态下，铜蓝蛋白均可提高上述大鼠器官中的cAMP/cGMP比值。
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