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[在给予不同程度辐射防护效果的化合物过程中小鼠血浆中的环腺苷酸-3',5'-磷酸和环鸟苷酸-3',5'-磷酸]

[Cyclic adenosine-3',5'-phosphate and guanosine-3',5'-phosphate in mouse plasma during administration of chemical compounds with different degrees of radioprotective effectiveness].

作者信息

Koterov A N, Nikol'skiĭ A V, Beketov V P, Pushkareva N B

出版信息

Radiobiologiia. 1986 Mar-Apr;26(2):195-200.

PMID:3010372
Abstract

A study was made of seven radioprotective agents of different chemical classes (sulfur-containing, indolylalkylamines, and imidazol, urea and pyridasine derivatives) and also of their six structural analogs without radioprotective properties on the content of cyclic nucleotides in blood plasma and on the postirradiation survival of mice. There was a correlation between the ability of the preparations to increase the level of cyclic adenosine-3',5'-monophosphate and their radioprotective properties; with guanosine-3',5'-monophosphate, this correlation was absent.

摘要

对七种不同化学类别的辐射防护剂(含硫化合物、吲哚烷基胺以及咪唑、尿素和吡啶哒嗪衍生物)及其六种无辐射防护特性的结构类似物进行了研究,观察它们对小鼠血浆中环核苷酸含量以及辐照后存活率的影响。制剂提高环腺苷 - 3',5'-单磷酸水平的能力与其辐射防护特性之间存在相关性;而与鸟苷 - 3',5'-单磷酸之间不存在这种相关性。

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