在大鼠摄入碳酸氢钠、氯化钠和氯化铵期间氢氯噻嗪的低钙尿作用。
Hypocalciuric effects of hydrochlorothiazide in the rat during NaHCO3, NaCl and NH4Cl loading.
作者信息
Goulding A, Campbell D
出版信息
Ren Physiol. 1984 May-Jun;7(3):185-91. doi: 10.1159/000172937.
PMID:6330816
Abstract
Hydrochlorothiazide (HCTZ) and NaHCO3 each lower urinary calcium excretion, while NaCl and NH4Cl each increase urinary calcium. This study examines the ability of HCTZ to lower urinary calcium during NaHCO3, NaCl and NH4Cl loading in the rat. We show that HCTZ lowers urinary calcium in rats treated with NaHCO3, NaCl and NH4Cl. We demonstrate that urinary calcium excretion is depressed to a greater degree by administering NaHCO3 and HCTZ in combination than by administering these agents separately.
摘要
氢氯噻嗪（HCTZ）和碳酸氢钠均可降低尿钙排泄，而氯化钠和氯化铵则均可增加尿钙排泄。本研究检测了在大鼠中给予碳酸氢钠、氯化钠和氯化铵负荷时，氢氯噻嗪降低尿钙的能力。我们发现，氢氯噻嗪可降低给予碳酸氢钠、氯化钠和氯化铵的大鼠的尿钙水平。我们还证明，联合给予碳酸氢钠和氢氯噻嗪比单独给予这两种药物更能显著降低尿钙排泄。
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