Kurtz T W, Morris R C
Life Sci. 1985 Mar 11;36(10):921-9. doi: 10.1016/0024-3205(85)90387-x.
In rats given desoxycorticosterone (DOC), the recently reported finding that a normal amount of dietary sodium chloride (NaCl) induces hypertension but an equimolar amount of sodium bicarbonate (NaHCO3) does not, might be a consequence of the differing effects of the two sodium salts on the metabolism of calcium. In accord with this hypothesis, we have found that, in uninephrectomized rats given DOC: Dietary NaCl induces persisting hypercalciuria and hypertension whereas an approximately equimolar amount of dietary NaHCO3 induces neither hypercalciuria nor hypertension. The urinary excretion of calcium becomes greater in rats given NaCl than in those given NaHCO3, before their blood pressures become different. Replacing dietary NaCl with a near equimolar amount of dietary NaHCO3 corrects both the hypercalciuria and the hypertension initially induced by NaCl.
在给予脱氧皮质酮（DOC）的大鼠中，最近报道的一项发现是，正常量的膳食氯化钠（NaCl）会诱发高血压，但等摩尔量的碳酸氢钠（NaHCO₃）则不会，这可能是两种钠盐对钙代谢产生不同影响的结果。根据这一假设，我们发现，在给予DOC的单侧肾切除大鼠中：膳食NaCl会诱发持续性高钙尿症和高血压，而等摩尔量的膳食NaHCO₃既不会诱发高钙尿症，也不会诱发高血压。在大鼠血压出现差异之前，给予NaCl的大鼠尿钙排泄量就比给予NaHCO₃的大鼠更大。用等摩尔量的膳食NaHCO₃替代膳食NaCl，可纠正最初由NaCl诱发的高钙尿症和高血压。
