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灭活脊髓灰质炎病毒疫苗诱导的免疫及病毒排泄

Immunity induced by inactivated poliovirus vaccine and excretion of virus.

作者信息

Chin T D

出版信息

Rev Infect Dis. 1984 May-Jun;6 Suppl 2:S369-70. doi: 10.1093/clinids/6.supplement_2.s369.

DOI:10.1093/clinids/6.supplement_2.s369
PMID:6330838
Abstract

Epidemiologic studies suggest that high levels of immunity induced by inactivated poliovirus vaccine could limit the spread of poliomyelitis in the community. Antibody induced by this vaccine had a marked effect on reducing pharyngeal virus excretion in children with poliovirus infection. Some reduction of fecal virus excretion was also observed, but high levels of serum antibody were required for this reduction.

摘要

流行病学研究表明，灭活脊髓灰质炎病毒疫苗诱导产生的高水平免疫力可限制脊髓灰质炎在社区中的传播。该疫苗诱导产生的抗体对减少脊髓灰质炎病毒感染儿童的咽部病毒排泄有显著作用。粪便病毒排泄也有一定程度的减少，但这种减少需要高水平的血清抗体。

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