Lapinleimu K
Rev Infect Dis. 1984 May-Jun;6 Suppl 2:S457-60. doi: 10.1093/clinids/6.supplement_2.s457.
In Finland paralytic poliomyelitis has disappeared after immunization programs carried out exclusively with inactivated poliovirus vaccine (IPV). A sharp decrease in the number of patients with poliomyelitis occurred after mass vaccination in 1960-1961, when 51% of the population had received the complete primary vaccination. Immunity is maintained by continuous vaccination of infants, whose vaccination rate is close to 98%. Intensive poliovirus surveillance in 1972-1974 revealed that dissemination of the virus has also virtually ceased. Serologic surveys indicate that greater than or equal to 90% of individuals older than 15 years of age possess antibodies to all viral types, but in the younger age groups the proportion with antibodies to types 1 and 3 is lower, a finding that is alarming, especially in the case of type 3. Revaccination of seronegative children and conscripts has induced rapid booster-like responses, indicating that fully vaccinated individuals, although without demonstrable antibodies, are protected against poliomyelitis. The new, improved IPV developed in Holland induces satisfactory antibody titers in all vaccinees, with two injections--or perhaps even one--leading to long-lasting immunity.
在芬兰，仅通过使用灭活脊髓灰质炎病毒疫苗（IPV）开展免疫规划后，麻痹性脊髓灰质炎已消失。1960 - 1961年大规模疫苗接种后，脊髓灰质炎患者数量急剧下降，当时51%的人口接受了完整的基础疫苗接种。通过持续为婴儿接种疫苗来维持免疫力，婴儿的疫苗接种率接近98%。1972 - 1974年的脊髓灰质炎病毒强化监测显示，病毒传播实际上也已停止。血清学调查表明，15岁以上的个体中超过或等于90%对所有病毒类型都具有抗体，但在较年轻年龄组中，对1型和3型病毒具有抗体的比例较低，这一发现令人担忧，尤其是对于3型病毒。对血清阴性儿童和应征入伍者进行再接种引发了快速的类似加强免疫的反应，表明完全接种疫苗的个体尽管没有可检测到的抗体，但仍受到脊髓灰质炎的保护。荷兰研发的新型改良IPV在所有接种者中诱导出令人满意的抗体滴度，注射两剂——甚至可能一剂——就能产生持久的免疫力。
