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人乳头瘤病毒DNA在体外诱导的细胞转化

Cellular transformation by human papillomavirus DNA in vitro.

作者信息

Watts S L, Phelps W C, Ostrow R S, Zachow K R, Faras A J

出版信息

Science. 1984 Aug 10;225(4662):634-6. doi: 10.1126/science.6330900.

DOI:10.1126/science.6330900
PMID:6330900
Abstract

Molecularly cloned DNA's of human papillomaviruses HPV-5 and HPV-l induced morphological transformation of mouse C127 cells in culture. Single-cell clones of cells transformed by papillomavirus contained multiple persistent episomal copies of the transfected DNA species and were analyzed for growth characteristics indicating malignant potential.

摘要

人乳头瘤病毒HPV - 5和HPV - 1的分子克隆DNA在培养中诱导小鼠C127细胞发生形态转化。由乳头瘤病毒转化的细胞的单细胞克隆含有转染DNA物种的多个持久性附加型拷贝，并对其表明恶性潜能的生长特性进行了分析。

相似文献

1
Cellular transformation by human papillomavirus DNA in vitro.人乳头瘤病毒DNA在体外诱导的细胞转化
Science. 1984 Aug 10;225(4662):634-6. doi: 10.1126/science.6330900.
2
Transformation of C127 mouse fibroblasts by human papillomavirus 16.
Cancer Res. 1988 May 1;48(9):2505-11.
3
Human papillomavirus type 6b DNA required for initiation but not maintenance of transformation of C127 mouse cells.人乳头瘤病毒6b型DNA是启动而非维持C127小鼠细胞转化所必需的。
J Virol. 1990 Mar;64(3):969-76. doi: 10.1128/JVI.64.3.969-976.1990.
4
Introduction of cloned human papillomavirus 1a DNA into rat fibroblasts: integration, de novo methylation and absence of cellular morphological transformation.将克隆的人乳头瘤病毒1a型DNA导入大鼠成纤维细胞：整合、从头甲基化及细胞形态未发生转化
J Gen Virol. 1985 May;66 ( Pt 5):1063-72. doi: 10.1099/0022-1317-66-5-1063.
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'Hit and run' oncogenesis by human papillomavirus type 18 DNA.人乳头瘤病毒18型DNA的“肇事逃逸”致癌作用
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Suppression of tumorigenesis by transcription units expressing the antisense E6 and E7 messenger RNA (mRNA) for the transforming proteins of the human papilloma virus and the sense mRNA for the retinoblastoma gene in cervical carcinoma cells.在宫颈癌细胞中，通过表达针对人乳头瘤病毒转化蛋白的反义E6和E7信使核糖核酸（mRNA）以及视网膜母细胞瘤基因的正义mRNA的转录单位来抑制肿瘤发生。
Cancer Gene Ther. 1995 Mar;2(1):19-32.
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Transformation of rat 3Y1 cells by a deletion DNA of human papillomavirus type 16 molecularly cloned from genomic DNA of a cervical carcinoma.
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Phenotypic transformation of primary mouse fibroblasts by BPV 1 DNA.
Arch Virol. 1988;100(1-2):17-25. doi: 10.1007/BF01310904.
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Analysis by polymerase chain reaction of the physical state of human papillomavirus type 16 DNA in cervical preneoplastic and neoplastic lesions.通过聚合酶链反应分析16型人乳头瘤病毒DNA在宫颈肿瘤前病变和肿瘤病变中的物理状态。
J Gen Virol. 1992 Sep;73 ( Pt 9):2327-36. doi: 10.1099/0022-1317-73-9-2327.
10
Epithelial differentiation fails to support replication of cloned human papillomavirus type 16 DNA in transfected keratinocytes.上皮分化无法支持克隆的人乳头瘤病毒16型DNA在转染角质形成细胞中的复制。
J Invest Dermatol. 1995 Feb;104(2):277-81. doi: 10.1111/1523-1747.ep12612814.

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HPV entry into cells.HPV 进入细胞。
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Prevalence of human papillomavirus DNA in cutaneous neoplasms from renal allograft recipients supports a possible viral role in tumour promotion.肾移植受者皮肤肿瘤中人乳头瘤病毒DNA的流行情况支持病毒在肿瘤促进中可能发挥的作用。
Br J Cancer. 1994 Feb;69(2):222-9. doi: 10.1038/bjc.1994.43.
4
Human papillomavirus 16 DNA in NIH3T3 cells transformed by colonic cancer cellular DNA.由结肠癌细胞DNA转化的NIH3T3细胞中的人乳头瘤病毒16型DNA
Gut. 1993 Dec;34(12):1710-3. doi: 10.1136/gut.34.12.1710.
5
The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein.人乳头瘤病毒6型和16型E5蛋白是与16千道尔顿孔形成蛋白相关的膜相关蛋白。
J Virol. 1993 Oct;67(10):6170-8. doi: 10.1128/JVI.67.10.6170-6178.1993.
6
Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.16型人乳头瘤病毒DNA与激活的ras协同作用转化原代细胞。
EMBO J. 1987 Jun;6(6):1741-6. doi: 10.1002/j.1460-2075.1987.tb02426.x.
7
Differential early viral gene expression in two stages of human papillomavirus type 16 DNA-induced malignant transformation.人乳头瘤病毒16型DNA诱导恶性转化两个阶段中病毒早期基因的差异表达
Mol Cell Biol. 1987 Jun;7(6):2165-72. doi: 10.1128/mcb.7.6.2165-2172.1987.
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Rat embryo fibroblast cells expressing human papillomavirus 1a genes exhibit altered growth properties and tumorigenicity.表达人乳头瘤病毒1a基因的大鼠胚胎成纤维细胞表现出生长特性改变和致瘤性。
J Virol. 1986 Dec;60(3):868-73. doi: 10.1128/JVI.60.3.868-873.1986.
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In vivo transformation of human skin with human papillomavirus type 11 from condylomata acuminata.用人乳头瘤病毒11型对尖锐湿 疣患者的人皮肤进行体内转化。
J Virol. 1986 Aug;59(2):369-76. doi: 10.1128/JVI.59.2.369-376.1986.
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Human papillomavirus type 16 DNA-induced malignant transformation of NIH 3T3 cells.人乳头瘤病毒16型DNA诱导NIH 3T3细胞发生恶性转化。
J Virol. 1986 Feb;57(2):572-7. doi: 10.1128/JVI.57.2.572-577.1986.