人乳头瘤病毒DNA在体外诱导的细胞转化
Cellular transformation by human papillomavirus DNA in vitro.
作者信息
Watts S L, Phelps W C, Ostrow R S, Zachow K R, Faras A J
出版信息
Science. 1984 Aug 10;225(4662):634-6. doi: 10.1126/science.6330900.
PMID:6330900
Abstract
Molecularly cloned DNA's of human papillomaviruses HPV-5 and HPV-l induced morphological transformation of mouse C127 cells in culture. Single-cell clones of cells transformed by papillomavirus contained multiple persistent episomal copies of the transfected DNA species and were analyzed for growth characteristics indicating malignant potential.
摘要
人乳头瘤病毒HPV - 5和HPV - 1的分子克隆DNA在培养中诱导小鼠C127细胞发生形态转化。由乳头瘤病毒转化的细胞的单细胞克隆含有转染DNA物种的多个持久性附加型拷贝，并对其表明恶性潜能的生长特性进行了分析。
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