[The rate of elimination of heterologous native and modified high-density lipoproteins from rabbit blood plasma after their intravenous administration].

Native and modified horse LPHD (methylated, succinylated, with blocked Arg-residues and COOH-groups) were administered intravenously (400 mg by protein) into healthy rabbits and into animals with hypercholesterolemia. Concentration of the modified LPHD decreased much more distinct in blood plasma of healthy rabbits as compared with native LPHD. The same results were obtained in rabbits with hypercholesterolemia after administration of methylated and succinylated LPHD. The higher rate of elimination of the modified LPHD appears to occur due to their phagocytosis by macrophages. The data obtained suggest that catabolism of LPHD in rabbits, contrary to LPLD catabolism, did not involve specific cell receptors.