Overgaard J
Acta Radiol Oncol. 1984;23(2-3):135-9. doi: 10.3109/02841868409136001.
An experimental model composed of a C3H mammary carcinoma and its surrounding skin has been exposed to simultaneous radiation and hyperthermia given with different combinations of heating time and temperature. Based on the thermal enhancement ratio (TER) values obtained in the temperature range 41.5 to 43.5 degrees C, a linear relationship between TER and the heating time was achieved at each temperature. The slopes of the curves drawn at each temperature were found to have a log-linear relationship with the treatment temperature. With these relationships it was possible to make a formula expressing the TER as a function of treatment temperature and time. This formula gives a crude but probably acceptable estimate of the TER following a single simultaneous radiation and heat treatment. Although subject to several limitations, the formula represents an attempt to describe a heat dose concept for the radiosensitizing effect of hyperthermia. This may be useful to establish the tolerance level of a given radiation treatment when combined with hyperthermia.
一种由C3H乳腺癌及其周围皮肤组成的实验模型，已接受了同时进行的放疗和热疗，热疗采用了不同的加热时间和温度组合。基于在41.5至43.5摄氏度温度范围内获得的热增强比（TER）值，在每个温度下，TER与加热时间之间都呈现出线性关系。发现在每个温度下绘制的曲线斜率与治疗温度具有对数线性关系。利用这些关系，可以得出一个将TER表示为治疗温度和时间函数的公式。该公式对单次同时进行放疗和热疗后的TER给出了一个粗略但可能可接受的估计。尽管该公式存在一些局限性，但它代表了一种尝试，用于描述热疗放射增敏效应的热剂量概念。这对于确定给定放疗与热疗联合时的耐受水平可能是有用的。
