呼吸速率与质子动力之间的关系。质子传导性的作用。
The relationship between the rate of respiration and the protonmotive force. The role of proton conductivity.
作者信息
O'Shea P S, Chappell J B
出版信息
Biochem J. 1984 Apr 15;219(2):401-4. doi: 10.1042/bj2190401.
Abstract
It is shown by titrating a suspension of rat liver mitochondria with either ADP or an uncoupler that a specific rate of respiration may not have a unique associated value of the protonmotive force. Alternatively, a specific protonmotive force may not be associated with a unique rate of respiration. It seems that the rate of respiration and the protonmotive force are more sensitive to the agents used for the titrations than to each other. Such observations are not easily explained by the chemiosmotic hypothesis. It is, however, possible provided that the proton conductivities, i.e. the rates of dissipation of the protonmotive force, are considered to be different for each of the agents used to titrate the rate of respiration at the same protonmotive force, or vice versa.
摘要
通过用ADP或解偶联剂滴定大鼠肝线粒体悬浮液表明，特定的呼吸速率可能没有唯一相关的质子动力势值。或者，特定的质子动力势可能与唯一的呼吸速率无关。似乎呼吸速率和质子动力势对用于滴定的试剂比对彼此更敏感。化学渗透假说不容易解释这些观察结果。然而，如果认为在相同质子动力势下用于滴定呼吸速率的每种试剂的质子电导率，即质子动力势的耗散速率是不同的，那么这就是可能的，反之亦然。
相似文献
1
The relationship between the rate of respiration and the protonmotive force. The role of proton conductivity.
Biochem J. 1984 Apr 15;219(2):401-4. doi: 10.1042/bj2190401.
2
On the role of the membrane proton conductance in the relationship between rate of respiration and protonmotive force.
Biochem J. 1985 Aug 1;229(3):833-7. doi: 10.1042/bj2290833.
3
The effects of partial uncoupling upon the kinetics of ATP synthesis by vesicles from Paracoccus denitrificans and by bovine heart submitochondrial particles. Implications for the mechanism of the proton-translocating ATP synthase.
Eur J Biochem. 1983 May 2;132(2):425-31. doi: 10.1111/j.1432-1033.1983.tb07380.x.
4
Altered relationship between protonmotive force and respiration rate in non-phosphorylating liver mitochondria isolated from rats of different thyroid hormone status.
Eur J Biochem. 1988 Dec 15;178(2):511-8. doi: 10.1111/j.1432-1033.1988.tb14477.x.
5
Experimental discrimination between proton leak and redox slip during mitochondrial electron transport.
Biochem J. 1994 Jan 1;297 ( Pt 1)(Pt 1):27-9. doi: 10.1042/bj2970027.
6
Effect of protonmotive force on the relative proton stoichiometries of the mitochondrial proton pumps.
Biochem J. 1991 Apr 1;275 ( Pt 1)(Pt 1):75-80. doi: 10.1042/bj2750075.
7
The nature of controlled respiration and its relationship to protonmotive force and proton conductance in blowfly flight-muscle mitochondria.
Biochem J. 1977 May 15;164(2):305-22. doi: 10.1042/bj1640305.
8
Thyroid hormone effects on the proton permeability of rat liver mitochondria.
Mol Cell Endocrinol. 1990 Jan 22;68(2-3):137-41. doi: 10.1016/0303-7207(90)90186-c.
9
Mechanisms of the deleterious effects of tamoxifen on mitochondrial respiration rate and phosphorylation efficiency.
Toxicol Appl Pharmacol. 2001 Nov 1;176(3):145-52. doi: 10.1006/taap.2001.9265.
10
[A correlation between respiration and synthesis of ATP in mitochondria at different degree of uncoupling of oxidative phosphorylation].
Biofizika. 2005 Jul-Aug;50(4):660-7.
引用本文的文献
1
The Slo(w) path to identifying the mitochondrial channels responsible for ischemic protection.
Biochem J. 2017 Jun 9;474(12):2067-2094. doi: 10.1042/BCJ20160623.
2
Membrane-potential-dependent changes of the lipid microviscosity of mitochondria and phospholipid vesicles.
Biochem J. 1984 Jun 15;220(3):795-801. doi: 10.1042/bj2200795.
3
Regulation of respiration and ATP synthesis in higher organisms: hypothesis.
J Bioenerg Biomembr. 1986 Feb;18(1):39-54. doi: 10.1007/BF00743611.
4
On the role of the membrane proton conductance in the relationship between rate of respiration and protonmotive force.
Biochem J. 1985 Aug 1;229(3):833-7. doi: 10.1042/bj2290833.
5
Release of respiratory control in Escherichia coli after bacteriophage adsorption: process independent of DNA injection.
J Bacteriol. 1985 Jan;161(1):179-82. doi: 10.1128/jb.161.1.179-182.1985.
6
An investigation of the relationships between rate and driving force in simple uncatalysed and enzyme-catalysed reactions with applications of the findings to chemiosmotic reactions.
Biochem J. 1992 Apr 15;283 ( Pt 2)(Pt 2):541-52. doi: 10.1042/bj2830541.
本文引用的文献
1
Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism.
Nature. 1961 Jul 8;191:144-8. doi: 10.1038/191144a0.
2
Mitochondrial transmembrane pH and electrical gradients: evaluation of their energy relationships with respiratory rate and adenosine 5'-triphosphate synthesis.
Biochemistry. 1982 Mar 16;21(6):1438-44. doi: 10.1021/bi00535a051.
3
Non-equilibrium thermodynamic assessment of redox-driven H+ pumps in mitochondria.
Eur J Biochem. 1982 Oct;127(3):483-94. doi: 10.1111/j.1432-1033.1982.tb06897.x.
4
Proton electrochemical gradients and energy-transduction processes.
Annu Rev Biochem. 1982;51:185-217. doi: 10.1146/annurev.bi.51.070182.001153.
5
Studies on the relationship between ATP synthesis and transport and the proton electrochemical gradient in rat liver mitochondria.
Biochim Biophys Acta. 1983 Apr 22;723(1):59-70. doi: 10.1016/0005-2728(83)90009-9.
6
The influence of respiration and ATP hydrolysis on the proton-electrochemical gradient across the inner membrane of rat-liver mitochondria as determined by ion distribution.
Eur J Biochem. 1974 Dec 16;50(1):305-15. doi: 10.1111/j.1432-1033.1974.tb03899.x.
7
Brown adipose tissue mitochondria.
Biochim Biophys Acta. 1979 Jul 3;549(1):1-29. doi: 10.1016/0304-4173(79)90016-8.
8
Proton conductance of the thylakoid membrane: modulation by light.
FEBS Lett. 1977 Jan 15;73(1):51-4. doi: 10.1016/0014-5793(77)80013-6.
Zotero 插件