论膜质子传导在呼吸速率与质子动力关系中的作用。
On the role of the membrane proton conductance in the relationship between rate of respiration and protonmotive force.
作者信息
Ghazi A
出版信息
Biochem J. 1985 Aug 1;229(3):833-7. doi: 10.1042/bj2290833.
Abstract
The rate of respiration in mitochondria is not a unique function of the protonmotive force, depending on whether the protonmotive force is varied by addition of ADP or uncouplers. This result has been generally considered to contradict the chemiosmotic theory. Recently, O'Shea & Chappell [Biochem. J. (1984) 219, 401-404] claimed that this observation can be reconciled with the chemiosmotic theory, provided only that the proton conductance of the membrane is different in the presence of ADP or uncouplers. This hypothesis is shown here to be necessary but not sufficient to account for the experimental data and the reason for the contradiction between this recent interpretation and earlier interpretations is pointed out.
摘要
线粒体中的呼吸速率并非质子动力的唯一函数，这取决于质子动力是通过添加ADP还是解偶联剂来改变。这一结果通常被认为与化学渗透理论相矛盾。最近，奥谢和查佩尔[《生物化学杂志》（1984年）219卷，401 - 404页]声称，只要膜在存在ADP或解偶联剂时的质子电导率不同，这一观察结果就可以与化学渗透理论相协调。本文表明，这一假设对于解释实验数据是必要的，但并不充分，并指出了这一最新解释与早期解释之间矛盾的原因。
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