Koskinen H, Järvisalo J, Pitkänen E, Mutanen P, Zitting A
Br J Dis Chest. 1984 Jul;78(3):217-24.
The serum activities of two lysosomal enzymes, beta-N-acetylglucosaminidase (EC 3.2.1.30; NAG) and beta-glucuronidase (EC 3.2.1.31; GLU) were analysed in 116 male patients with silicosis. Twenty-eight of the patients were matched with controls of similar sex, age and exposure to silica dust but with no radiographical evidence of silicosis. A control group which had not been exposed to silica dust consisted of male blood donors. The mean activity of NAG in serum was higher in the silicosis patients than in the blood donors (P less than 0.01). Similarly, the NAG level in the silicosis patients with matched controls was higher than that in the silica-exposed controls (P less than 0.05). The silicosis patients who showed a progression of small opacities by one or more subcategories had a slightly higher mean NAG activity in their sera than the patients with no progression but this difference did not reach statistical significance; the activity was higher than in silica-exposed controls (P less than 0.05). We suggest that these findings may be related to the effects of silica on macrophages which have been observed experimentally in vitro and in vivo and might indicate an increased turnover of macrophages caused by silica dust and active, progressive silicotic fibrosis.
对116例男性矽肺患者的两种溶酶体酶，即β-N-乙酰氨基葡萄糖苷酶（EC 3.2.1.30；NAG）和β-葡萄糖醛酸酶（EC 3.2.1.31；GLU）的血清活性进行了分析。其中28例患者与性别、年龄和接触二氧化硅粉尘情况相似但无矽肺影像学证据的对照组进行匹配。未接触二氧化硅粉尘的对照组由男性献血者组成。矽肺患者血清中NAG的平均活性高于献血者（P<0.01）。同样，与匹配对照组的矽肺患者相比，接触二氧化硅的对照组中NAG水平更高（P<0.05）。小阴影进展一个或多个亚类的矽肺患者血清中NAG的平均活性略高于无进展的患者，但这种差异未达到统计学意义；其活性高于接触二氧化硅的对照组（P<0.05）。我们认为，这些发现可能与二氧化硅对巨噬细胞的作用有关，这在体外和体内实验中均已观察到，可能表明二氧化硅粉尘和活跃的进行性矽肺纤维化导致巨噬细胞更新增加。
