孔隙结构对能垒和外加电压分布的影响。II. 不对称通道。
Effect of pore structure on energy barriers and applied voltage profiles. II. Unsymmetrical channels.
作者信息
Jordan P C
出版信息
Biophys J. 1984 Jun;45(6):1101-7. doi: 10.1016/s0006-3495(84)84258-7.
Abstract
This paper examines "realistic" pores, i.e., ones that are neither symmetric nor of uniform diameter. Methods are described that permit estimation of the image potential for an ion in an aqueous pore spanning a lipid membrane and for the electric field produced in such a pore when a transmembrane potential is applied. They are used to model features of the delayed rectifier potassium channel. Constraints on the geometry of the exterior mouth, the dielectric properties of the narrow part of the pore and the conduction mechanism are determined for this channel.
摘要
本文研究“实际的”孔道，即既不对称孔径也不均匀的孔道。文中描述了一些方法，这些方法可用于估算跨越脂质膜的水性孔道中离子的图像电势，以及施加跨膜电势时该孔道中产生的电场。这些方法被用于模拟延迟整流钾通道的特征。针对该通道，确定了孔道外口几何形状、孔道狭窄部分的介电特性以及传导机制的限制条件。
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