膜结合型乙酰胆碱受体的晶体阵列

Kistler J, Stroud R M

Proc Natl Acad Sci U S A. 1981 Jun;78(6):3678-82. doi: 10.1073/pnas.78.6.3678.

Electron micrographs of tubular structures with a crystalline arrangement of membrane-bound acetylcholine receptor oligomers have been analyzed by digital image reconstruction. The receptor molecules are oriented synaptic side out, and in projection they appear to be asymmetric and have a defined orientation. All four subunits are contained in the oligomers as demonstrated by immunoelectron microscopy; these structures therefore appear to be suitable for subunit localization in the oligomer.

通过数字图像重建分析了具有膜结合乙酰胆碱受体寡聚体晶体排列的管状结构的电子显微照片。受体分子以突触侧向外的方向排列，在投影中它们似乎是不对称的并且具有确定的方向。免疫电子显微镜证明所有四个亚基都包含在寡聚体中；因此这些结构似乎适用于寡聚体中亚基的定位。