Nadaud D, Herman J P, Simon H, Le Moal M
Brain Res. 1984 Jun 18;304(1):137-41. doi: 10.1016/0006-8993(84)90869-2.
Lesion of mesolimbic dopaminergic neurons induces hypoactivity and hypo-exploration in a new environment, lack of hyperactivity to amphetamine and hyperresponsiveness to apomorphine. Transplantation of embryonic dopaminergic cells from rat embryos into the deafferented nucleus accumbens restores, 8 weeks after grafting, some of the deficits obtained after the lesion. Spontaneous activity and behavioral responses in an open-field are improved and some of the grafted rats show a complete recovery of amphetamine-induced hyperactivity. However, hyperresponsiveness to apomorphine has not been significantly reduced by the treatment. These results indicate that transplanted dopaminergic neurons can restore some of the functional activities of the n. accumbens.
中脑边缘多巴胺能神经元损伤会导致在新环境中活动减少和探索行为减弱，对苯丙胺缺乏多动反应以及对阿扑吗啡反应过度。将大鼠胚胎的胚胎多巴胺能细胞移植到去传入的伏隔核中，移植8周后，可恢复损伤后出现的部分缺陷。旷场实验中的自发活动和行为反应得到改善，一些移植大鼠的苯丙胺诱导的多动完全恢复。然而，治疗并未显著降低对阿扑吗啡的过度反应。这些结果表明，移植的多巴胺能神经元可恢复伏隔核的部分功能活动。
