Kelly P H, Roberts D C
Pharmacol Biochem Behav. 1983 Jul;19(1):137-43. doi: 10.1016/0091-3057(83)90322-2.
Spontaneous locomotor activity was markedly elevated by electrolytic lesions of the nucleus accumbens. This was true whether or not the dopaminergic input to this nucleus was previously destroyed by injection of 6-hydroxydopamine (6-OHDA) into the region. In animals with electrolytic lesions the locomotor stimulant action of d-amphetamine sulfate (1.5 mg/kg SC) was occluded, while a moderately low dose of apomorphine (0.25 mg/kg SC) produced a striking decrease of locomotor activity. The results are consistent with the view that the efferents of neurons in the nucleus accumbens exert an inhibitory influence on locomotor activity. Hyperactivity results when these efferents are destroyed. The results are also consistent with the view that the locomotor depressant action of apomorphine is mediated, at least partly, by an action at a site other than the nucleus accumbens.
伏隔核的电解损伤显著提高了自发运动活性。无论之前是否通过向该区域注射6-羟基多巴胺（6-OHDA）破坏了该核团的多巴胺能输入，情况都是如此。在有电解损伤的动物中，硫酸右旋苯丙胺（1.5毫克/千克，皮下注射）的运动兴奋作用被阻断，而中等低剂量的阿扑吗啡（0.25毫克/千克，皮下注射）则使运动活性显著降低。这些结果与以下观点一致，即伏隔核中神经元的传出纤维对运动活性发挥抑制作用。当这些传出纤维被破坏时就会出现多动。这些结果也与以下观点一致，即阿扑吗啡的运动抑制作用至少部分是通过作用于伏隔核以外的部位介导的。
