Effects of amphetamine and apomorphine on locomotor activity after 6-OHDA and electrolytic lesions of the nucleus accumbens septi.

Spontaneous locomotor activity was markedly elevated by electrolytic lesions of the nucleus accumbens. This was true whether or not the dopaminergic input to this nucleus was previously destroyed by injection of 6-hydroxydopamine (6-OHDA) into the region. In animals with electrolytic lesions the locomotor stimulant action of d-amphetamine sulfate (1.5 mg/kg SC) was occluded, while a moderately low dose of apomorphine (0.25 mg/kg SC) produced a striking decrease of locomotor activity. The results are consistent with the view that the efferents of neurons in the nucleus accumbens exert an inhibitory influence on locomotor activity. Hyperactivity results when these efferents are destroyed. The results are also consistent with the view that the locomotor depressant action of apomorphine is mediated, at least partly, by an action at a site other than the nucleus accumbens.