Thies P W, Dull W L
Arch Intern Med. 1984 Aug;144(8):1691-2. doi: 10.1001/archinte.144.8.1691.
Trimethoprim-sulfamethoxazole is known to produce hepatitis. We report a case involving the inadvertent rechallenge with trimethoprim-sulfamethoxazole (Bactrim) in a patient with a previous episode of drug-induced hepatitis. A liver biopsy specimen showed both cholestatic and cytotoxic changes consistent with drug-induced damage. Comparison with existing cases is presented and an immunologic cause is considered.
已知甲氧苄啶-磺胺甲恶唑可引发肝炎。我们报告了一例病例，一名曾有药物性肝炎发作史的患者意外再次接受了甲氧苄啶-磺胺甲恶唑（复方新诺明）治疗。肝脏活检标本显示出与药物性损伤相符的胆汁淤积性和细胞毒性改变。文中对现有病例进行了比较，并探讨了免疫方面的病因。
