Angarano G, Carlone A, Ieva R, Luchena N, Pastore G
Boll Soc Ital Biol Sper. 1984 May 30;60(5):955-60.
The pathogenesis of the hepatic damage in hepatitis is not well understood but an imbalance in immunoregulatory T lymphocytes is probable. We tested the Theophylline-sensitive T lymphocytes in acute and protracted cases of hepatitis A, in hepatitis B and non-A, non-B. A delayed increment of such cells was demonstrated in hepatitis B suggesting a positive role in the recovery from the disease. The results were indicative for a direct action of the HAV and nAnB on the lymphocytes. Theophylline-sensitive lymphocytes were increased in the course of protracted hepatitis A whereas were progressively decreasing in nAnB hepatitis. This behaviour of suppressor cells in nAnB hepatitis may explain the high frequency of evolution in chronic liver disease.
肝炎中肝损伤的发病机制尚未完全明确，但免疫调节性T淋巴细胞失衡很可能是其原因。我们检测了甲型肝炎急性和迁延性病例、乙型肝炎以及非甲非乙型肝炎中对茶碱敏感的T淋巴细胞。在乙型肝炎中证实此类细胞有延迟性增加，提示其在疾病恢复过程中起积极作用。结果表明甲型肝炎病毒（HAV）和非甲非乙型肝炎病毒（nAnB）对淋巴细胞有直接作用。在迁延性甲型肝炎病程中，对茶碱敏感的淋巴细胞增加，而在非甲非乙型肝炎中则逐渐减少。非甲非乙型肝炎中抑制性细胞的这种行为可能解释了慢性肝病高发生率的原因。
