Rawlings N C, Ward W R
J Reprod Fertil. 1978 Mar;52(2):249-54. doi: 10.1530/jrf.0.0520249.
Fetal hypophysectomy performed between 97 and 130 days of gestation caused a significant (P is less than 0.005) prolongation of pregnancy in 5 goats in which every fetus was treated. Three of these goats gave birth spontaneously. Sham surgery or hypophysectomy of one fetus of twins had no effect on gestation length. Hypophysectomized kids, delivered after prolonged pregnancy, were significantly heavier than normal term kids (P is less than 0.005) and had lighter adrenals (P is less than 0.025). Measurements of maternal peripheral plasma concentrations of progesterone and total unconjugated oestrogens showed that the changes in goats carrying hypophysectomized fetuses were similar to those of normal pregnancy except that the prepartum oestrogen peak was absent, whether or not parturition occurred spontaneously.
在妊娠97至130天之间对5只山羊进行胎儿垂体切除术，每只胎儿均接受治疗，结果导致妊娠显著延长（P<0.005）。其中3只山羊自然分娩。对双胞胎之一进行假手术或垂体切除术对妊娠期长度没有影响。在延长妊娠期后分娩的垂体切除胎儿的幼崽比足月正常幼崽显著更重（P<0.005），肾上腺更轻（P<0.025）。对母体外周血孕酮和总未结合雌激素浓度的测量表明，携带垂体切除胎儿的山羊的变化与正常妊娠相似，只是无论是否自然分娩，产前雌激素峰值均不存在。
