Lammertsma A A, Brooks D J, Beaney R P, Turton D R, Kensett M J, Heather J D, Marshall J, Jones T
J Cereb Blood Flow Metab. 1984 Sep;4(3):317-22. doi: 10.1038/jcbfm.1984.47.
A method is described for measuring the regional cerebral-to-large vessel haematocrit ratio using inhalation of carbon-11-labelled carbon monoxide and the intravenous injection of carbon-11-labelled methyl-albumin in combination with positron emission tomography. The mean value in a series of nine subjects was 0.69. This is approximately 20% lower than the value of 0.85 previously reported. It is concluded that previous measurements of regional cerebral blood volume using a haematocrit ratio of 0.85 will have underestimated the value of regional cerebral blood volume by 20%.
描述了一种通过吸入碳-11标记的一氧化碳并静脉注射碳-11标记的甲基白蛋白，结合正电子发射断层扫描来测量局部脑与大血管血细胞比容比值的方法。九名受试者的一系列测量平均值为0.69。这比先前报道的0.85的值低约20%。得出的结论是，先前使用0.85的血细胞比容比值测量局部脑血容量会低估局部脑血容量值20%。
