Lyt-1 cells mediate acute murine experimental allergic encephalomyelitis.
作者信息
Hauser S L, Weiner H L, Bhan A K, Shapiro M E, Che M, Aldrich W R, Letvin N L
出版信息
J Immunol. 1984 Nov;133(5):2288-90.
PMID:6332841
Abstract
Adult SJL/J mice were depleted of T lymphocytes and were reconstituted with Lyt-1, Lyt-2, or Lyt-1 + Lyt-2 cells. After immunization with MSCH, severe acute EAE developed in the Lyt-1- and the Lyt-1 + Lyt-2-reconstituted mice. Only 25% of the Lyt-2-reconstituted mice developed signs of EAE, and in those EAE onset was delayed. Thus, Lyt-1 cells mediate EAE in the mouse.
摘要
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