Korngold R, Feldman A, Rorke L B, Lublin F D, Doherty P C
Immunogenetics. 1986;24(5):309-15. doi: 10.1007/BF00395536.
Acute experimental allergic encephalomyelitis (EAE) is an autoimmune disease involving the central nervous system (CNS) that can be elicited in susceptible strains of mice by the subcutaneous inoculation of mouse spinal cord homogenate (MSCH) in conjunction with complete Freund's adjuvant. In order to localize the physiological compartment conveying susceptibility to mice for EAE induction, hematopoietic radiation chimeras were prepared between the highly responsive SJL and low responder B10.S strains. Upon challenge with SJL MSCH preparations, high incidence of clinical disease was exhibited by B10.S----SJL chimeras but not by SJL----B10.S mice, suggesting that non-bone-marrow-derived factors were influencing development of disease. The incidence of histological lesions in the CNS was high for virtually all experimental and control groups except normal B10.S and B10.S----B10.S reconstituted mice. In contrast, challenge with B10.S MSCH induced a high clinical incidence of EAE in both B10.S----SJL and SJL----B10.S chimeras, indicating a possible interstrain difference in the immunogenicity of relevant CNS antigens.
急性实验性变应性脑脊髓炎（EAE）是一种累及中枢神经系统（CNS）的自身免疫性疾病，通过将小鼠脊髓匀浆（MSCH）与完全弗氏佐剂联合皮下接种，可在易感品系小鼠中诱发该病。为了定位对小鼠诱导EAE具有易感性的生理区室，在高反应性的SJL和低反应性的B10.S品系之间制备了造血辐射嵌合体。用SJL MSCH制剂攻击后，B10.S→SJL嵌合体出现了高发病率的临床疾病，而SJL→B10.S小鼠则未出现，这表明非骨髓来源的因素在影响疾病的发展。除正常B10.S和B10.S→B10.S重建小鼠外，几乎所有实验组和对照组的中枢神经系统组织学损伤发生率都很高。相反，用B10.S MSCH攻击在B10.S→SJL和SJL→B10.S嵌合体中均诱发了高发病率的EAE临床疾病，表明相关中枢神经系统抗原的免疫原性可能存在品系间差异。
