Gilbert D N, Eubanks N M, Jackson J M
J Med Educ. 1978 Feb;53(2):129-34. doi: 10.1097/00001888-197802000-00008.
This report describes the effect of a combined education and monitoring program on the use of gentamicin in a community hospital. The use of gentamicin was evaluated in 82 patients prior to an education program and in 80 patients after the education program. The results indicate that the attention focused on gentamicin by the study significantly improved the valid indications for treatment from 75% to 87% (p less than .05), increased the pretreatment use of bacteriologic cultures from 85% to 97% (p less than .05), increased the use of alternative less toxic antibiotics from 36% to 75% (p less than .05), and increased the frequency with which serum gentamicin concentrations were requested during therapy from 28% to 56% (p less than .001). Thus, the data support the tenet that the ways antibiotics are employed in community hospitals can be altered.
本报告描述了一项联合教育与监测项目对一家社区医院庆大霉素使用情况的影响。在开展教育项目之前，对82名患者使用庆大霉素的情况进行了评估；在教育项目之后，又对80名患者进行了评估。结果表明，该研究对庆大霉素的关注显著改善了治疗的有效指征，从75%提高到了87%（p小于0.05），将治疗前细菌培养的使用率从85%提高到了97%（p小于0.05），将毒性较小的替代抗生素的使用率从36%提高到了75%（p小于0.05），并将治疗期间要求检测血清庆大霉素浓度的频率从28%提高到了56%（p小于0.001）。因此，数据支持这样一个原则，即社区医院使用抗生素的方式是可以改变的。
