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神经毒性化合物1-甲基-苯基-四氢吡啶从大鼠中枢神经系统组织中释放氚标记单胺的体外研究

In vitro release of tritiated monoamines from rat CNS tissue by the neurotoxic compound 1-methyl-phenyl-tetrahydropyridine.

作者信息

Schmidt C J, Matsuda L A, Gibb J W

出版信息

Eur J Pharmacol. 1984 Aug 17;103(3-4):255-60. doi: 10.1016/0014-2999(84)90485-0.

DOI:10.1016/0014-2999(84)90485-0
PMID:6333347
Abstract

The effects of the neurotoxic compound, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (1-MPTP), on monoamine release was determined using slices of rat corpus striatum or cerebral cortex preloaded with [3H]dopamine or [3H]serotonin, respectively. 1-MPTP released both monoamines in a concentration-dependent manner. [3H]Dopamine release was unaffected by tetrodotoxin, the absence of Ca2+, and nicotinic or muscarinic cholinergic antagonists. Dopamine uptake inhibitors had no effect on release from normal striatal slices but appeared to attenuate 1-MPTP-induced release from striatal slices of reserpine-pretreated rats.

摘要

使用分别预先加载了[3H]多巴胺或[3H]5-羟色胺的大鼠纹状体或大脑皮层切片，测定神经毒性化合物1-甲基-4-苯基-1,2,3,6-四氢吡啶（1-MPTP）对单胺释放的影响。1-MPTP以浓度依赖性方式释放两种单胺。[3H]多巴胺的释放不受河豚毒素、无Ca2+以及烟碱或毒蕈碱胆碱能拮抗剂的影响。多巴胺摄取抑制剂对正常纹状体切片的释放没有影响，但似乎减弱了1-MPTP诱导的利血平预处理大鼠纹状体切片的释放。

相似文献

1
In vitro release of tritiated monoamines from rat CNS tissue by the neurotoxic compound 1-methyl-phenyl-tetrahydropyridine.神经毒性化合物1-甲基-苯基-四氢吡啶从大鼠中枢神经系统组织中释放氚标记单胺的体外研究
Eur J Pharmacol. 1984 Aug 17;103(3-4):255-60. doi: 10.1016/0014-2999(84)90485-0.
2
Neurochemical investigations in vitro with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in preparations of rat brain.利用1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）对大鼠脑制备物进行体外神经化学研究。
Eur J Pharmacol. 1984 Nov 13;106(2):301-11. doi: 10.1016/0014-2999(84)90717-9.
3
Comparison of 1-methyl-4-(p-chlorophenyl)-1,2,3,6-tetrahydropyridine, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and p-chloroamphetamine as monoamine depletors.1-甲基-4-（对氯苯基）-1,2,3,6-四氢吡啶、1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）和对氯苯丙胺作为单胺耗竭剂的比较。
Res Commun Chem Pathol Pharmacol. 1985 Oct;50(1):57-65.
4
Systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine reduces the release of [3H]dopamine from rat striatal slices.全身给予1-甲基-4-苯基-1,2,3,6-四氢吡啶可减少大鼠纹状体切片中[3H]多巴胺的释放。
Eur J Pharmacol. 1989 Oct 4;169(1):147-52. doi: 10.1016/0014-2999(89)90826-1.
5
Dopamine-releasing action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) in the neostriatum of the rat as demonstrated in vivo by the push-pull perfusion technique: dependence on sodium but not calcium ions.用推挽灌注技术在大鼠体内证实1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）和1-甲基-4-苯基吡啶（MPP+）在新纹状体中的多巴胺释放作用：依赖钠离子而非钙离子。
Brain Res. 1988 Mar 8;443(1-2):101-16. doi: 10.1016/0006-8993(88)91603-4.
6
Comparison of the effects of two 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs, 1-methyl-4-(2-thienyl)-1,2,3,6-tetrahydropyridine and 1-methyl-4-(3-thienyl)-1,2,3,6-tetrahydropyridine, on monoamine oxidase in vitro and on dopamine in mouse brain.两种1-甲基-4-苯基-1,2,3,6-四氢吡啶类似物，即1-甲基-4-(2-噻吩基)-1,2,3,6-四氢吡啶和1-甲基-4-(3-噻吩基)-1,2,3,6-四氢吡啶，对体外单胺氧化酶及小鼠脑内多巴胺作用的比较
J Pharmacol Exp Ther. 1987 Feb;240(2):415-20.
7
Effect of cysteine on the persistent depletion of brain monoamines by amphetamine, p-chloroamphetamine and MPTP.
Eur J Pharmacol. 1987 Jan 13;133(2):191-7. doi: 10.1016/0014-2999(87)90150-6.
8
Effects of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine and related compounds on the uptake of [3H]3,4-dihydroxyphenylethylamine and [3H]5-hydroxytryptamine in neostriatal synaptosomal preparations.1-甲基-4-苯基-1,2,5,6-四氢吡啶及相关化合物对新纹状体突触体制剂中[3H]3,4-二羟基苯乙胺和[3H]5-羟色胺摄取的影响。
J Neurochem. 1985 Jan;44(1):310-3. doi: 10.1111/j.1471-4159.1985.tb07146.x.
9
Effect of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) on monoamine neurotransmitters in mouse brain & heart.1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）对小鼠脑和心脏中单胺神经递质的影响。
Life Sci. 1984 Jul 16;35(3):285-91. doi: 10.1016/0024-3205(84)90112-7.
10
Serotonergic conversion of MPTP and dopaminergic accumulation of MPP+.MPTP的5-羟色胺能转化和MPP+的多巴胺能蓄积
FEBS Lett. 1985 Sep 23;189(2):225-30. doi: 10.1016/0014-5793(85)81028-0.

引用本文的文献

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MPTP and SNpc DA neuronal vulnerability: role of dopamine, superoxide and nitric oxide in neurotoxicity. Minireview.MPTP与黑质致密部多巴胺能神经元易损性：多巴胺、超氧化物和一氧化氮在神经毒性中的作用。综述。
Neurotox Res. 2005;7(3):193-202. doi: 10.1007/BF03036449.
2
Inhibition by dizocilpine (MK-801) of striatal dopamine release induced by MPTP and MPP+: possible action at the dopamine transporter.地佐环平（MK-801）对MPTP和MPP⁺诱导的纹状体多巴胺释放的抑制作用：可能作用于多巴胺转运体
Br J Pharmacol. 1995 Jan;114(2):315-22. doi: 10.1111/j.1476-5381.1995.tb13229.x.
3
An in vitro model of 1-methyl-4-phenyl-pyridinium (MPP+) toxicity: incubation of rabbit caudate nucleus slices with MPP+ followed by biochemical and functional analysis.
1-甲基-4-苯基吡啶离子（MPP+）毒性的体外模型：兔尾状核切片与MPP+孵育，随后进行生化和功能分析。
Br J Pharmacol. 1988 Oct;95(2):449-58. doi: 10.1111/j.1476-5381.1988.tb11665.x.
4
Inhibition of K+-stimulated [3H]dopamine and [14C]acetylcholine release by the putative dopamine autoreceptor agonist, B-HT 920.假定的多巴胺自身受体激动剂B-HT 920对钾离子刺激的[3H]多巴胺和[14C]乙酰胆碱释放的抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1986 Dec;334(4):377-82. doi: 10.1007/BF00569373.