对恶唑酮免疫反应的精细特异性。IV. 恶唑酮特异性溶细胞性T淋巴细胞（与抗体不同）不存在交叉反应性。
Fine-specificity of the immune response to oxazolones. IV. Furyloxazolone-specific cytolytic T lymphocytes (unlike antibodies) are not heteroclitic.
作者信息
Matoso-Ferreira A
出版信息
Immunology. 1984 Nov;53(3):451-6.
Antibodies, raised in CBA and C3H mice, to a hapten 2-furyloxazolone (furyl Ox) have a strange (heteroclitic) fine-specificity, having a higher affinity for the chemical analogue 2-styryloxazolone (styryl Ox) than for furyl Ox. Other mouse strains were found to produce 'normal' anti-furyl Ox antibodies, and the heteroclicity was inherited as an Igh allotype-linked trait (Mäkelä, Matoso-Ferreira & Kaartinen 1983). Hapten-specific cytolytic T lymphocytes (CTL) were generated by painting cyclophosphamide-treated mice with chemically reactive haptens, furyl Ox and styryl Ox, and their fine-specificity was investigated. Cytolytic cells generated in this way were 'homoclitic' in all cases, showing a preference for targets coupled with the homologous haptens (the immunogens).
在CBA和C3H小鼠中产生的针对半抗原2-呋喃恶唑酮（呋喃基恶唑酮）的抗体具有奇怪的（异向性的）精细特异性，对化学类似物2-苯乙烯基恶唑酮（苯乙烯基恶唑酮）的亲和力比对呋喃基恶唑酮的亲和力更高。发现其他小鼠品系产生“正常的”抗呋喃基恶唑酮抗体，并且这种异向性作为一种与免疫球蛋白同种异型相关的性状遗传（马凯拉、马托索-费雷拉和卡尔蒂宁，1983年）。通过用化学反应性半抗原呋喃基恶唑酮和苯乙烯基恶唑酮涂抹经环磷酰胺处理的小鼠来产生半抗原特异性细胞毒性T淋巴细胞（CTL），并研究它们的精细特异性。以这种方式产生的细胞毒性细胞在所有情况下都是“同向性的”，表现出对与同源半抗原（免疫原）偶联的靶标的偏好。
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