Kano Y, Sakamoto S, Sakuraya K, Kubota T, Taguchi H, Miura Y, Takaku F
J Lab Clin Med. 1984 Nov;104(5):711-7.
Results of the deoxyuridine suppression test, a good marker for defining biochemical megaloblastosis caused by deficiency of folate and vitamin B12, became abnormal (greater than 10%) after 6 hours of administration of nitrous oxide anesthesia. 5-Formyltetrahydrofolate and methylcobalamin administration during nitrous oxide anesthesia have no remarkable effect on the correction of deoxyuridine suppression test values. On the other hand, 5-formyltetrahydrofolate and methylcobalamin administrated at the end of nitrous oxide anesthesia corrected the abnormal deoxyuridine suppression test values nearly to normal range within 1 hour.
脱氧尿苷抑制试验结果是用于定义由叶酸和维生素B12缺乏引起的生化巨幼细胞贫血的良好指标，在一氧化二氮麻醉给药6小时后该指标变得异常（大于10%）。在一氧化二氮麻醉期间给予5-甲酰四氢叶酸和甲钴胺对纠正脱氧尿苷抑制试验值没有显著效果。另一方面，在一氧化二氮麻醉结束时给予5-甲酰四氢叶酸和甲钴胺可在1小时内将异常的脱氧尿苷抑制试验值纠正至接近正常范围。
