Del Zompo M, Bocchetta A, Goldin L R, Corsini G U
Acta Psychiatr Scand. 1984 Sep;70(3):282-7. doi: 10.1111/j.1600-0447.1984.tb01210.x.
Pedigrees of manic-depressive patients in treatment at the Lithium Clinic of the Institute of Clinical Pharmacology, University of Cagliari, were evaluated for linkage between major affective illness and the protan-deutan-glucose-6-phosphate-dehydrogenase region of the X-chromosome. Two informative pedigrees were found, investigated and analyzed for linkage using a multigenerational model and considering age-dependent penetrance. The results are consistent with the hypothesis of X-linkage in major affective illness.
对在卡利亚里大学临床药理研究所锂盐诊所接受治疗的躁郁症患者的家系进行了评估，以研究重性情感障碍与X染色体上的红色盲-绿色盲-葡萄糖-6-磷酸脱氢酶区域之间的连锁关系。发现了两个提供信息的家系，使用多代模型并考虑年龄依赖性外显率对其进行连锁研究和分析。结果与重性情感障碍X连锁假说一致。
