Mendlewicz J, Linkowski P, Wilmotte J
Br J Psychiatry. 1980 Oct;137:337-42. doi: 10.1192/bjp.137.4.337.
Hereditary has been shown to be an important factor in the aetiology of manic-depressive psychosis. Recent linkage studies with colour blindness have suggested the presence of an X-linked dominant gene in the transmission of manic-depressive psychosis. We report here positive evidence of a linkage between manic-depressive psychosis and glucose-6-phosphate dehydrogenase deficiency in an informative family assorting for both traits. These results strengthen previous linkage studies in affective illness and support the hypothesis of X-linkage in a subgroup of manic-depressive psychosis.
遗传因素已被证明是躁狂抑郁症病因中的一个重要因素。最近关于色盲的连锁研究表明，在躁狂抑郁症的遗传中存在一个X连锁显性基因。我们在此报告一个信息丰富的家族中，躁狂抑郁症与葡萄糖-6-磷酸脱氢酶缺乏症之间存在连锁的阳性证据，该家族同时具有这两种性状。这些结果加强了先前对情感性疾病的连锁研究，并支持了躁狂抑郁症亚组中X连锁的假说。
