Tamaki N, Yonekura Y, Mukai T, Kodama S, Kadota K, Kambara H, Kawai C, Torizuka K
J Am Coll Cardiol. 1984 Dec;4(6):1213-21. doi: 10.1016/s0735-1097(84)80140-0.
Stress thallium-201 myocardial distribution was quantitatively evaluated by emission transaxial tomography in 104 patients who underwent coronary arteriography. The initial uptake and percent washout of thallium were assessed by the circumferential profile curves of the three short-axis sections and one middle right anterior oblique long-axis section. This quantitative tomographic analysis showed abnormal distribution in all but two patients (98%) with coronary artery disease, whereas qualitative analysis showed abnormality in 76 of the patients (93%). Quantitative analysis showed better sensitivity (91%) for detecting involved coronary vessels than qualitative analysis (80%, p less than 0.01), especially in three vessel disease (82 versus 67%, p less than 0.05). For localization of individual vessel involvement, quantitative analysis showed high sensitivity (right coronary artery: 96%, left anterior descending artery: 90% and left circumflex artery: 88%) as compared with qualitative analysis (88, 83 and 63%, respectively, p less than 0.05), while similar specificity was observed (92% for quantitative and 93% for qualitative analyses). Furthermore, in the study of patients without infarction, myocardial segments supplied by coronary vessels with moderate stenosis (51 to 75%) revealed abnormality more often with quantitative (81%) than with qualitative (56%) analysis. Thus, quantitative analysis of stress thallium emission tomography provides improved sensitivity for the detection of diseased coronary vessels in patients with three vessel disease and those with moderate stenosis. It is a valuable technique for the evaluation of coronary artery disease.
对104例接受冠状动脉造影的患者，通过发射型断层摄影术对负荷铊-201心肌分布进行了定量评估。通过三个短轴切面和一个右前斜位中间长轴切面的圆周轮廓曲线评估铊的初始摄取和洗脱百分比。这种定量断层分析显示，除两名患者外，所有冠心病患者（98%）均存在异常分布，而定性分析显示76例患者（93%）存在异常。定量分析在检测受累冠状动脉血管方面显示出比定性分析更高的敏感性（91%对80%，p<0.01），尤其是在三支血管病变中（82%对67%，p<0.05）。对于单个血管受累的定位，定量分析显示出比定性分析更高的敏感性（右冠状动脉：96%，左前降支动脉：90%，左旋支动脉：88%）（定性分析分别为88%、83%和63%，p<0.05），而特异性相似（定量分析为92%，定性分析为93%）。此外，在无梗死患者的研究中，由中度狭窄（51%至75%）冠状动脉供血的心肌节段，定量分析（81%）比定性分析（56%）更常显示异常。因此，负荷铊发射断层摄影术的定量分析提高了对三支血管病变和中度狭窄患者中病变冠状动脉血管的检测敏感性。它是评估冠状动脉疾病的一项有价值的技术。
