Pollak R, Myers R A
J Trauma. 1978 Feb;18(2):121-3. doi: 10.1097/00005373-197802000-00008.
One hundred consecutive cases of trauma with associated fractures of the lower limb long bones were studied for the subsequent development of the fat embolism syndrome (FES). This is to be differentiated from the intravascular fat embolism which often occurs without clinical FES becoming manifest. Seventeen of the patients developed the clinical picture, with a further 16 patients being considered to have had the syndrome subclinically. Clinical and biochemical features were studied to determine pointers to the early diagnosis and patient "at risk" of developing FES. Young males under the age of 30 with significant hypoxemia occurring early in the course of the disease were considered the most likely candidates "at risk" for developing FES. These results favor the concept that FES is essentially a form of respiratory insufficiency syndrome similar to that which occurs following trauma in other situations, e.g., shock lung.
对连续100例伴有下肢长骨骨折的创伤病例进行研究，以观察脂肪栓塞综合征（FES）的后续发展情况。这需要与血管内脂肪栓塞相区分，血管内脂肪栓塞常常发生，但并无明显的临床FES表现。17例患者出现了临床症状，另有16例患者被认为有亚临床综合征。对临床和生化特征进行了研究，以确定早期诊断的指标以及发生FES的“高危”患者。30岁以下的年轻男性在病程早期出现明显低氧血症，被认为是最有可能发生FES的“高危”人群。这些结果支持了这样一种观点，即FES本质上是一种呼吸功能不全综合征，类似于其他情况下创伤后发生的情况，如休克肺。
