Campo-López C, Flors-Villaverde P, Calabuig-Alborch J R
Servicio de Medicina Interna, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Rev Clin Esp. 2012 Nov;212(10):482-7. doi: 10.1016/j.rce.2012.06.011. Epub 2012 Sep 13.
To review the incidence, clinical features, diagnosis, therapy and mortality rates of fat embolism syndrome (FES) in a tertiary referral hospital in the last decade.
Retrospective and descriptive study of patients diagnosed with post-traumatic FES between january 2001 and december 2011.
A total of 19 patients, 16 men and 3 women, with an average age of 27 years were evaluated. All had long bone fractures, multiple in 78.9%, as a result of multiple injuries. Respiratory symptoms were the most frequent (89.5%), followed by neurological symptoms (68.4%) and petechial rash (63.2%). The average time of presentation of the syndrome after admission was 42 hours. All patients underwent early stabilisation of the fracture prior to the embolic event. Steroids prophylaxis was not used in any of the cases. Definitive surgical treatment had mean delay of 7 days. The mean hospital stay was 34 days. The overall incidence of FES was 0.14%, and mortality was 10.5%.
Post-traumatic FES mainly affected young patients with multiple injuries and long bone fractures. They all had symptoms of the classic clinical triad (respiratory, neurological, rash) after an initial asymptomatic period of less than 2 days. The overall incidence was low.
回顾过去十年间一家三级转诊医院脂肪栓塞综合征（FES）的发病率、临床特征、诊断、治疗及死亡率。
对2001年1月至2011年12月间诊断为创伤后FES的患者进行回顾性描述性研究。
共评估了19例患者，其中男性16例，女性3例，平均年龄27岁。所有患者均有长骨骨折，78.9%为多发骨折，由多处损伤所致。呼吸系统症状最为常见（89.5%），其次是神经系统症状（68.4%）和瘀点皮疹（63.2%）。综合征在入院后出现的平均时间为42小时。所有患者在栓塞事件发生前均接受了骨折的早期固定。所有病例均未使用类固醇预防。确定性手术治疗的平均延迟时间为7天。平均住院时间为34天。FES的总体发病率为0.14%，死亡率为10.5%。
创伤后FES主要影响有多处损伤和长骨骨折的年轻患者。他们在初始无症状期少于2天后均出现了典型临床三联征（呼吸、神经、皮疹）的症状。总体发病率较低。
