Lersch C, Hammer C, Ganghoff O, Meyer J, Brendel W, Krombach F, Nath G
Oncology. 1984;41(6):442-5. doi: 10.1159/000225873.
Infrared contact coagulation (ICC) was evaluated in 3 different tumor models. 56-94% of all tumor-bearing rats, hamsters or mice were cured by ICC, whereas 100% of the controls died. The possibility that long-lasting immunological resistance might develop against the tumor after ICC was investigated by repeated tumor challenge. Cytotoxicity against tumor cells of host thymocytes and splenocytes following ICC was demonstrated in a Winn assay. The production of a mainly T-cell-dependent immune response could be due to ICC-induced antigenic changes in the tumor cells.
在3种不同的肿瘤模型中对红外接触凝固法（ICC）进行了评估。通过ICC治愈了56%-94%的荷瘤大鼠、仓鼠或小鼠，而100%的对照组动物死亡。通过重复肿瘤攻击研究了ICC后是否可能产生针对肿瘤的持久免疫抗性。在Winn试验中证实了ICC后宿主胸腺细胞和脾细胞对肿瘤细胞的细胞毒性。主要由T细胞介导的免疫反应的产生可能是由于ICC诱导肿瘤细胞发生了抗原变化。
