Pauwels E K, Cleton F J
Radiother Oncol. 1984 Mar;1(4):333-8. doi: 10.1016/s0167-8140(84)80021-3.
This review describes the state of the art for scintigraphic tumour detection using radiolabelled very pure (monoclonal) antibodies. In vivo imaging by scintigraphy may be useful for visualisation of cancer sites and treatment monitoring in oncologic patients. Imaging includes the computer-assisted processing of the scintigrams to remove background and non-target radioactivity. The clinical use of this method ("radioimmunoscintigraphy") depends, however, on the availability of the desired antibodies. Developments in the field of antibody labelling and emission tomography in the upcoming years are crucial for the usefulness of radioimmunoscintigraphy in daily practice.
本综述描述了使用放射性标记的超纯（单克隆）抗体进行肿瘤闪烁显像检测的技术现状。闪烁扫描法进行体内成像可能有助于可视化肿瘤部位以及监测肿瘤患者的治疗情况。成像包括对闪烁图进行计算机辅助处理，以去除背景和非靶标放射性。然而，这种方法（“放射免疫闪烁显像”）的临床应用取决于所需抗体的可获得性。未来几年抗体标记和发射断层扫描领域的发展对于放射免疫闪烁显像在日常实践中的实用性至关重要。
