O'Grady L F, DeNardo G, DeNardo S
Department of Internal Medicine, University of California, Davis, Medical Center, Sacramento 95817.
Am J Physiol Imaging. 1986;1(1):44-53.
Methods currently available to the clinician for the detection and localization of cancer are not specific and may have reached their technical limits. Deficiencies of these methods are detailed, and an ideal system for cancer detection is presented. Monoclonal antibodies directed against tumor antigens and labelled with radionuclides approach the ideal as a method for cancer screening, detection, localization, monitoring, and, perhaps, therapy. The production and radiolabelling of monoclonal antibodies are reviewed, and recent technical developments for imaging are explained. Methods to manipulate the system to achieve specific goals are outlined, and examples are shown. Metastases of certain tumors are demonstrated. The method holds great potential for diagnosis, monitoring, and even for radiotherapy of target tumors. Clinical trials are now in progress.
临床医生目前可用于癌症检测和定位的方法并不具有特异性，而且可能已达到其技术极限。本文详细阐述了这些方法的不足之处，并提出了一种理想的癌症检测系统。针对肿瘤抗原的单克隆抗体并用放射性核素标记，作为一种癌症筛查、检测、定位、监测乃至治疗的方法，已接近理想状态。本文综述了单克隆抗体的生产和放射性标记，并解释了近期的成像技术发展。概述了为实现特定目标而操纵该系统的方法，并给出了示例。展示了某些肿瘤的转移情况。该方法在目标肿瘤的诊断、监测甚至放射治疗方面具有巨大潜力。目前临床试验正在进行中。
