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[慢性风湿病中附着点病的系统研究。结果及病理意义。与侵蚀性脊柱炎及其他肌腱或滑膜病变的关系]

[Systematic research on enthesopathies in chronic rheumatism. Results and pathological significance. Relation to erosive spondylitis and other tendinous or synovial lesions].

作者信息

Paolaggi J B, Struz P, Goutet M C, Le Parc J M, Siaud J R, Auquier L

出版信息

Rev Rhum Mal Osteoartic. 1984 Oct;51(9):451-6.

PMID:6334351
Abstract

A routine investigation for rheumatic tendon lesions was conducted in 47 patients with an inflammatory spondylo-arthropathy and in 30 patients with rheumatoid arthritis. The incidence of tendon lesions (calcaneal and extra-calcaneal) differed very significantly (p less than 0.001) between the two groups (58.3% of patients with inflammatory spondylo-arthropathy had at least one tendon lesion, 6.6% of patients with rheumatoid arthritis). These results and data from the literature suggest that rheumatic tendon lesions are a characteristic feature of spondylo-arthropathy in the same way as sacro-iliitis, the absence of subcutaneous nodules, the absence of rheumatoid factor and the high incidence of histocompatibility antigen HLA B27. Together with this diagnostic value, there is also a histopathological value: inflammatory and ossifying tendinitis contrasts with the destructive synovitis of rheumatoid arthritis and can be considered to be a "sign" of inflammatory spondylo-arthropathy. Tendinitis and juxta-articular bone lesions in the limbs, so-called "peripheral" lesions, are similar to the vertebral lesions around the intervertebral disk and the posterior interapophyseal joints found in inflammatory spondylo-arthropathy. These lesions seem to be a common pathological feature, at least in part, with the polyarthropathies of childhood.

摘要

对47例炎症性脊柱关节病患者和30例类风湿关节炎患者进行了风湿性肌腱病变的常规调查。两组之间肌腱病变(跟骨和跟骨外)的发生率差异非常显著(p<0.001)(58.3%的炎症性脊柱关节病患者至少有一处肌腱病变,类风湿关节炎患者为6.6%)。这些结果以及文献数据表明,风湿性肌腱病变是脊柱关节病的一个特征性表现,就如同骶髂关节炎、无皮下结节、无类风湿因子以及组织相容性抗原HLA B27的高发生率一样。除了这种诊断价值外,还有组织病理学价值:炎症性和骨化性肌腱炎与类风湿关节炎的破坏性滑膜炎形成对比,可被视为炎症性脊柱关节病的一个“体征”。四肢的肌腱炎和关节周围骨病变,即所谓的“外周”病变,类似于在炎症性脊柱关节病中发现的椎间盘周围和后关节突关节周围的脊柱病变。这些病变似乎至少在部分程度上是儿童多关节病的一个共同病理特征。

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