一项关于人血浆来源的免疫抑制性抗淋巴瘤因子的研究。

Studies with a human plasma-derived immunosuppressive, anti-lymphoma factor.

作者信息

Farmer J L, Prager M D

出版信息

Cancer Immunol Immunother. 1984;18(2):101-6. doi: 10.1007/BF00205742.

DOI:10.1007/BF00205742

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11039212/

Abstract

A low-molecular-weight (1,400) factor isolated from a human plasma alpha-globulin concentrate by acid-salt dissociation and ultrafiltration inhibits proliferation of mitogen-stimulated T cells and L1210 leukemia cells. The factor (UM05R) inhibits DNA, RNA, and protein synthesis in sensitive cells, acts in G1 of the cell cycle, and appears to suppress mitogen-responsive T cells without an accessory cell requirement. UM05R activity is enhanced by known cAMP-elevating agents and by sulfhydryl compounds. The results of the present study are consistent with the hypothesis that the plasma-derived agent inhibits lympho-proliferation as a result of elevation of intracellular cAMP.

摘要

通过酸盐解离和超滤从人血浆α-球蛋白浓缩物中分离出的一种低分子量（1400）因子可抑制丝裂原刺激的T细胞和L1210白血病细胞的增殖。该因子（UM05R）抑制敏感细胞中的DNA、RNA和蛋白质合成，作用于细胞周期的G1期，并且似乎在无需辅助细胞的情况下抑制丝裂原反应性T细胞。已知的环磷酸腺苷（cAMP）升高剂和巯基化合物可增强UM05R的活性。本研究结果与以下假设一致：血浆衍生因子通过提高细胞内cAMP来抑制淋巴细胞增殖。

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