Miller F
Transplantation. 1976 Mar;21(3):179-87. doi: 10.1097/00007890-197603000-00001.
Two alpha-globulin fractions which had in vivo and in vitro immunosuppressive activity were prepared from human serum. The larger fraction eluted from a molecular sieving gel in the albumin fraction and was heat labile whereas the smaller one was present in the elute fraction containing materials of 8,000-25,000 daltons and was heat stable. It is believed that the smaller of the two fractions is the immunoregulatory alpha-globulin described by several other investigators. The comparative activities of various starting materials and of partially purified derivatives in several systems (in vivo and in vitro) were examined. The possibility that these substances are lymphocytic chalones is considered.
从人血清中制备出了两种在体内和体外均具有免疫抑制活性的α球蛋白组分。从分子筛凝胶中洗脱出来的较大组分存在于白蛋白组分中，且对热不稳定，而较小的组分则存在于含有8000 - 25000道尔顿物质的洗脱组分中，并且对热稳定。据信，这两种组分中较小的一种就是其他几位研究者所描述的免疫调节性α球蛋白。研究了多种起始材料和部分纯化衍生物在多个系统（体内和体外）中的比较活性。还考虑了这些物质是淋巴细胞抑素的可能性。
