Fedin Iu V, Ermilova V D
Vopr Onkol. 1984;30(11):38-44.
A study of 65 cases of breast cancer patients showed a complex interrelation between morphological characteristics (grade of malignancy, lymphoid infiltration, level of sinus histiocytosis and lymphoid hyperplasia in lymph nodes), clinical data (stage of the disease and extent of metastatic spread) and the results of immunological tests such as spontaneous rosette-formation and blastogenic reaction of lymphocytes. The level of lymphoid infiltration was found to be in direct correlation with that of tumor differentiation and in reverse correlation with patents' age. Cases exhibiting sinus histiocytosis developed metastases with a lower frequency. An increase in the level of lymphoid hyperplasia in lymph nodes was observed at early stages of tumor dissemination. A considerable drop in blastogenic reaction of lymphocytes was registered in cases of lymphoid infiltration-free tumors. Lymphoid hyperplasia in lymph nodes was associated with a lowered B-lymphocyte count in peripheral blood. A drop in the frequency of lymphoid infiltration was registered in patients with a stable decrease in the level of T-lymphocytes in the course of treatment. Also, clinical course was notably unfavorable in cases of lymphoid infiltration who responded well to treatment.
一项针对65例乳腺癌患者的研究表明，形态学特征（恶性程度、淋巴细胞浸润、窦组织细胞增生水平及淋巴结中的淋巴细胞增生）、临床数据（疾病分期及转移扩散范围）与免疫测试结果（如淋巴细胞的自发玫瑰花结形成和母细胞化反应）之间存在复杂的相互关系。研究发现，淋巴细胞浸润水平与肿瘤分化程度呈正相关，与患者年龄呈负相关。出现窦组织细胞增生的病例发生转移的频率较低。在肿瘤播散的早期阶段，观察到淋巴结中淋巴细胞增生水平有所增加。在无淋巴细胞浸润的肿瘤病例中，淋巴细胞的母细胞化反应显著下降。淋巴结中的淋巴细胞增生与外周血中B淋巴细胞计数降低有关。在治疗过程中T淋巴细胞水平持续下降的患者中，淋巴细胞浸润频率降低。此外，对治疗反应良好的淋巴细胞浸润病例的临床病程明显不利。
