Berglund L, Halldin C, Lilja A, Lindberg B S, Lundqvist H, Långström B, Malmborg P, Någren K, Stålnacke C G
Acta Obstet Gynecol Scand. 1984;63(7):641-5. doi: 10.3109/00016348409155554.
By use of Positron Emission Tomography (PET), dynamic studies of the metabolism within the feto-maternal unit can be performed using various tracers. Many compounds like amino acids, carbohydrates, fatty acids and drugs can be performed using various tracers. Many compounds like amino acids, carbohydrates, fatty acids and drugs can be labelled with 11C and used as tracers. 11C-labelled L- or D-methionine was injected intravenously into pregnant Rhesus monkeys. The distribution of the radioactivity in maternal muscles, aorta, placenta and the liver of the fetus was quantitatively estimated as a function of time. Simultaneously blood, urine and amniotic fluid samples were analyzed for 11C-activity. The distribution of 11C between the high and the low molecular fraction of plasma (MW greater than 5000) was studied after gel filtration. Both when 11C-L- and D-methionine were given, the radioactivity rapidly crossed the placenta and was accumulated in the fetal liver. In the 11C-L-methionine experiments, about 70 per cent of the radioactivity in plasma was found in the high molecular fraction one hour after injection. A greater part of 11C-D-compared to 11C-L-activity was excreted in the urine.
通过使用正电子发射断层扫描（PET），可以使用各种示踪剂对母胎单位内的代谢进行动态研究。许多化合物，如氨基酸、碳水化合物、脂肪酸和药物，都可以用作各种示踪剂。许多化合物，如氨基酸、碳水化合物、脂肪酸和药物，可以用11C标记并用作示踪剂。将11C标记的L-或D-蛋氨酸静脉注射到怀孕的恒河猴体内。作为时间的函数，定量估计母体肌肉、主动脉、胎盘和胎儿肝脏中放射性的分布。同时，对血液、尿液和羊水样本进行11C活性分析。凝胶过滤后，研究了11C在血浆高分子和低分子部分（分子量大于5000）之间的分布。当给予11C-L-和D-蛋氨酸时，放射性都迅速穿过胎盘并在胎儿肝脏中积累。在11C-L-蛋氨酸实验中，注射后一小时，血浆中约70%的放射性存在于高分子部分。与11C-L-活性相比，11C-D-活性的更大一部分从尿液中排出。
