Janczarski M, Ruszkowska I, Cetnarowicz H, Lopaciuk S
Samodzielnej Pracowni Krzepniecia Krwi i Hemostazy Instytutu Hematologii w Warszawie.
Acta Haematol Pol. 1990 Jan-Jun;21(1):16-21.
Following an intravenous infusion of DDAVP in a single dose of 0.3 microgram/kg b.w. and subsequent infusion of 4 g of epsilon-aminocaproic acid, 28 tooth extractions have been performed in 18 patients with mild haemophilia A and 5 patients with type I von Willebrand's disease. During the subsequent 7-10 days, the patients received epsilon-aminocaproic acid orally. In 89% of cases the healing was uneventful and no bleeding complications occurred. A single infusion of DDAVP and epsilon-aminocaproic acid was also effective for the management of muscle hematoma ++ and haemarthroses in 4 of the 7 mildly affected haemophiliacs. In the remaining 3, the symptoms of bleeding subsided following repeated infusion of DDAVP. The results indicate that a single intravenous infusions of DDAVP when combined with the administration of antifibrinolytic agents can insure sufficient haemostasis after tooth extraction and is useful for the management of muscle hematoma and hemarthroses in patients with mild haemophilia A mild von Willebrand's disease.
以0.3微克/千克体重的单剂量静脉输注去氨加压素，随后输注4克氨甲环酸后，对18例轻度甲型血友病患者和5例Ⅰ型血管性血友病患者进行了28次拔牙。在随后的7 - 10天里，患者口服氨甲环酸。89%的病例愈合顺利，未发生出血并发症。单次输注去氨加压素和氨甲环酸对7例轻度受累血友病患者中的4例的肌肉血肿++和关节积血的治疗也有效。其余3例在反复输注去氨加压素后出血症状消退。结果表明，单次静脉输注去氨加压素并联合使用抗纤溶药物可确保拔牙后充分止血，对轻度甲型血友病和轻度血管性血友病患者的肌肉血肿和关节积血的治疗有效。
