[Intravenous administration of deamino-D-arginine-vasopressin (DDAVP) to patients with hemophilia A and von Willebrand's disease].

Following an intravenous infusion of DDAVP in a single dose of 0.3 microgram/kg b.w. and subsequent infusion of 4 g of epsilon-aminocaproic acid, 28 tooth extractions have been performed in 18 patients with mild haemophilia A and 5 patients with type I von Willebrand's disease. During the subsequent 7-10 days, the patients received epsilon-aminocaproic acid orally. In 89% of cases the healing was uneventful and no bleeding complications occurred. A single infusion of DDAVP and epsilon-aminocaproic acid was also effective for the management of muscle hematoma ++ and haemarthroses in 4 of the 7 mildly affected haemophiliacs. In the remaining 3, the symptoms of bleeding subsided following repeated infusion of DDAVP. The results indicate that a single intravenous infusions of DDAVP when combined with the administration of antifibrinolytic agents can insure sufficient haemostasis after tooth extraction and is useful for the management of muscle hematoma and hemarthroses in patients with mild haemophilia A mild von Willebrand's disease.