Daley T D, Wysocki G P
J Periodontol. 1984 Dec;55(12):708-12. doi: 10.1902/jop.1984.55.12.708.
Cyclosporine is a relatively new immunosuppressive agent which has been used successfully to prevent organ transplant rejection, to treat type-I diabetes mellitus as well as several other autoimmune disorders. It is anticipated that the therapeutic use of cyclosporine will progressively increase in the future to include the treatment of numerous other disorders. As its clinical use broadens, more health professionals will need to become familiar with the beneficial effects as well as some of the undesirable side-effects of cyclosporine therapy. Two side-effects of the drug which are of interest to the periodontist are gingival hyperplasia and transient perioral hyperaesthesia. It is anticipated that the dental profession, particularly periodontists, will be called upon to help prevent, control or treat these side effects. The purpose of this paper is to familiarize the periodontist with cyclosporine and to discuss its anticipated impact on the practice of periodontics.
环孢素是一种相对较新的免疫抑制剂，已成功用于预防器官移植排斥反应、治疗I型糖尿病以及其他几种自身免疫性疾病。预计未来环孢素的治疗用途将逐渐增加，涵盖众多其他疾病的治疗。随着其临床应用范围的扩大，更多的医疗专业人员将需要熟悉环孢素治疗的有益效果以及一些不良副作用。牙周病医生感兴趣的该药物的两种副作用是牙龈增生和短暂的口周感觉过敏。预计牙科行业，尤其是牙周病医生，将被要求协助预防、控制或治疗这些副作用。本文的目的是使牙周病医生熟悉环孢素，并讨论其对牙周病治疗实践的预期影响。
