Fraser-Smith E B, Eppstein D A, Marsh Y V, Matthews T R
Antimicrob Agents Chemother. 1984 Dec;26(6):937-8. doi: 10.1128/AAC.26.6.937.
The acyclic nucleoside DHPG [9-(1,3-dihydroxy-2-propoxymethyl)guanine] and recombinant human alpha-interferon of clones A/D potentiate each other's antiviral activity against a systemic infection with herpes simplex virus type 2. The effective dose at which 50% of the mice survived was lowered approximately 10-fold for DHPG when it was given in combination with a marginally effective dose of alpha-interferon and greater than 10-fold for alpha-interferon when it was given in combination with a nontherapeutic dose of DHPG.
无环核苷DHPG [9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤]与克隆A/D的重组人α干扰素对单纯疱疹病毒2型全身感染的抗病毒活性具有协同增强作用。当DHPG与低有效剂量的α干扰素联合使用时,使50%小鼠存活的有效剂量降低了约10倍;当α干扰素与非治疗剂量的DHPG联合使用时,其有效剂量降低超过10倍。