阿昔洛韦与人类白细胞干扰素联合使用对人类疱疹病毒的抑制作用
Inhibition of human herpesviruses by combination of acyclovir and human leukocyte interferon.
作者信息
Levin M J, Leary P L
出版信息
Infect Immun. 1981 Jun;32(3):995-9. doi: 10.1128/iai.32.3.995-999.1981.
Abstract
Human leukocytes interferon in low concentrations (1 to 5 U/ml) enhanced the antiviral effect of acyclovir against herpes simplex virus, varicella-zoster virus, and cytomegalovirus grown in human fibroblasts. This occurred without additive inhibition of the division of human fibroblasts or proliferation of peripheral blood mononuclear cells. The combined antiviral effect was additive against clinical isolates of cytomegalovirus and was synergistic against clinical isolates of the other two viruses. The magnitude of the effect with cytomegalovirus was the same when laboratory and wild-type virus were compared. The persistence of varicella-zoster virus in the presence of acyclovir in infected human cells was also reduced by the addition of interferon.
摘要
低浓度（1至5 U/ml）的人白细胞干扰素增强了阿昔洛韦对在人成纤维细胞中生长的单纯疱疹病毒、水痘带状疱疹病毒和巨细胞病毒的抗病毒作用。这种情况发生时，并未额外抑制人成纤维细胞的分裂或外周血单核细胞的增殖。联合抗病毒作用对巨细胞病毒临床分离株具有相加作用，对其他两种病毒的临床分离株具有协同作用。比较实验室病毒和野生型病毒时，对巨细胞病毒的作用强度相同。添加干扰素也降低了水痘带状疱疹病毒在感染的人细胞中与阿昔洛韦同时存在时的持续性。
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