Wirth R, Volf V
Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Dec;46(6):787-92. doi: 10.1080/09553008414552021.
This interim report summarizes the results of observations during the first year after a single injection of 237Np nitrate (0.2 or 1.0 mg/kg body weight) into adult female rats and further preliminary data obtained with young animals. The retention of 237Np was followed by whole body counting and serial sacrifice of groups of animals. The retention data could be fitted to three-component exponential equations which show no major differences between the two 237Np dose levels. The half-times and extrapolated initial fractions calculated from the first two exponential terms indicate that one fraction, representing about 40 per cent of the injected 237Np was excreted within the first 5 days and an additional 15 per cent within the first 5 months, while the rest was excreted with a half-time of about 3.5 years. This final long term component is assumed to indicate the rate of loss of 237Np from the skeletal compartment. In young animals both whole-body and skeletal retention of 237Np during the first 5 months of observation was about 50 per cent higher than in the adults. Several soft tissue tumours, mostly mammary tumours, have appeared to approximately the same extent in both control and 237Np treated adult rats but no osteosarcomas were detected up to 15 months after injection of 237Np.
本中期报告总结了成年雌性大鼠单次注射硝酸钚-237（0.2或1.0毫克/千克体重）后第一年的观察结果，以及幼龄动物的进一步初步数据。通过全身计数和对动物组进行系列处死来追踪钚-237的滞留情况。滞留数据可以用三成分指数方程拟合，结果显示两个钚-237剂量水平之间没有重大差异。从前两个指数项计算得出的半衰期和外推初始分数表明，一个组分约占注入钚-237的40%，在最初5天内排出，另有15%在最初5个月内排出，其余部分以约3.5年的半衰期排出。假定这一最后的长期组分表明了钚-237从骨骼区室的流失速率。在幼龄动物中，观察的前5个月内钚-237的全身和骨骼滞留量比成年动物高约50%。在对照成年大鼠和接受钚-237处理的成年大鼠中，均出现了几种软组织肿瘤，主要是乳腺肿瘤，但在注射钚-237后15个月内未检测到骨肉瘤。
